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KMID : 0882420170920010024
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Korean Journal of Medicine
2017 Volume.92 No. 1 p.24 ~ p.35
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Updated Treatment of Chronic Hepatitis C
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Kim Young-Seok
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Abstract
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Hepatitis C virus (HCV) infection is one of the important causes of chronic liver diseases, including hepatic fibrosis, liver cirrhosis and hepatocellular carcinoma. The goals of hepatitis C treatment are to eradicate HCV and to prevent related hepatic complications, manifestations of HCV infection and death. A sustained virological response (SVR) is defined as undetectable serum HCV RNA by a sensitive assay at 12 or 24 weeks after treatment completion. The infection is cured in nearly 100% of patients who achieve an SVR. Newly introduced direct-acting antivirals act at a specific step of the viral life cycle and enable an SVR of over 90%. There are a number of unmet needs in HCV therapies that should be addressed, and are anticipated to be resolved in the near future.
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KEYWORD
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Hepatitis C, Chronic, Treatment
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